Clinical Experience with Sugammadex as a Neuromuscular Reversal Agent: A 10-Patient - Case Series

• Dr Naba Madoo

  Author

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Background: Sugammadex is a novel selective relaxant binding agent used for the rapid and effective reversal 
of aminosteroid-induced neuromuscular blockade. 
Objective: To evaluate the clinical efficacy, safety, and recovery characteristics associated with sugammadex in 
10 patients undergoing elective surgery. 
Methods: Ten adult patients receiving rocuronium-induced neuromuscular blockade for elective surgical 
procedures were administered sugammadex at standard doses based on blockade depth. Train-Of-Four (TOF) 
ratios were monitored, and time to recovery (TOF ≥ 0.9), adverse events, extubation time, and PACU duration 
were recorded. 
Results: All patients achieved a TOF ratio ≥ 0.9 within 140–230 seconds (mean: 177.5 ± 30.6 seconds) post
administration. No adverse events or hemodynamic instability were observed. Extubation was performed 
promptly, with PACU durations ranging from 35–60 minutes. 
Conclusion: Sugammadex enabled rapid and reliable neuromuscular recovery with minimal side effects, 
supporting its role as a safe and effective reversal agent in elective surgical settings.

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